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On the heels of the widely publicized failure of anti-amyloid approaches to curing Alzheimer's, a lot of publicity has been given to another approach known as "Tau" (Neuro-Fibrillary Tangles or NFT) as a therapeutic target for Alzheimer's, as highlighted in last week's International Conference on Alzheimer's Disease in Chicago. Experts at Anavex Life Sciences Corp. (AVXL.OB) (http://www.anavex.
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1. Wnt Effects on Growth Cone Microtubules Silvia A. Purro, Lorenza Ciani, Monica Hoyos-Flight, Eleanna Stamatakou, Eliza Siomou, and Patricia C. Salinas Wnt family proteins are secreted from target tissues and regulate axonal terminal arborization during development. In the canonical Wnt pathway, Wnt signals through the phosphoprotein Dishevelled, which leads to inhibition of the kinase Gsk3, elevation of β-catenin, and activation of transcription. Purro et al.
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Teenagers who don't sleep well or long enough may have a higher risk of elevated blood pressure that could lead to cardiovascular disease later in life, researchers report in Circulation: Journal of the American Heart Association. Researchers found the odds of elevated blood pressure increased 3.5 times for those with low sleep efficiency and 2.5 times for those with sleeping periods of less than 6.
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    December 21, 2007, 08:03
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    December 21, 2007, 23:49
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